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Reported Adverse Reactions include:

• nausea, vomiting, dyspepsia
• hypotension, dizziness
• constipation
• taste disturbances
• peripheral edema
• erythema
• decreased sensation
• decreased motor strength, weakness
• acute hepatitis (jaundice, RUQ pain, elevated liver enzymes)
• hypercalcemia

Interactions with Herbs & Supplements:

• Calcium - Shark cartilage has a high level of calcium.  Using shark cartilage with a calcium supplement will increase the likelihood of hypercalcemia

Interactions with Drugs:

• None known

Interactions with Foods:

• Fruit Juice - Acidic fruit juices may decrease the potency of shark cartilage over time.

Additional Warnings:

• Because shark cartilage has been shown to inhibit angiogenesis, pregnant and breastfeeding women should avoid taking this supplement.
• Because shark cartilage has such a high calcium content it could be problematic in individuals with renal disease or individuals at risk for arrhythmias.
• It should not be taken after surgery or trauma because its antiangiogenic effects could interfere with wound healing