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In 1983, researchers at the Massachusetts Institute of Technology published a study showing that shark cartilage has the ability to inhibit blood vessel growth (angiogenesis).  The public interest in shark cartilage grew when Dr. I. Williiam Lane published his book, Sharks Don't Get Cancer -- How Shark Cartilage Could Save Your Life.  Dr. Lane discusses how inhibition of angiogenesis can halt tumor growth and prevent cancer metastasis.  His extensive research of shark cartilage has led him to conclusion that shark cartilage can inhibit angiogenesis and is, therefore, effective against cancer, as well as other conditions, such as arthritis, psoriasis and enteritis.  His most well known work was conducted in Cuba and consisted of giving shark cartilage to 29 nonresponsive terminal cancer patients.  This work was extensively covered by 60 Minutes' Mike Wallace.  The airing of this 60 Minutes edition marked the start of the shark cartilage "craze."

Currently, there are more than 40 different brand names of shark cartilage available to consumers.  Because dietary supplements are regulated as foods, rather than drugs, the FDA does not evaluate these various brands of shark cartilage.  The FDA has recognized the potential benefit of shark cartilage.  To conduct clinical drug research, investigators must first file an Investigational New Drug (IND) application with the FDA.  The IND status has been granted to at least 4 groups of investigators who are studying shark cartilage as a cancer treatment.