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- In 2005 a metaanalysis by Miller et al in the Annals of Internal Medicine found that high dose Vitamin E supplements may increase all-cause mortality. (2005 Jan 4; 142(1) 37-46). - The team looked at the dose response relationship between vitamin E supplementation and total mortality using data from randomized control trials. - 135,967 participants in 19 clinical trials. Of the trials, 9 tested vitamin E alone and 10 tested vitamin E with other vitamins and minerals. Doses ranged from 16.5 to 2000IU/d (median 400 IU/d). The team reviewed sources from 1966 to 2004. - 9 of 11 trials testing high dose vitamin E (> or = 400 IU/d) showed an increase risk for all cause mortality for vitamin E versus control. The pooled all-cause mortality risk difference in high dose vitamin E trials was 39/10000 ( 95% CI, 3 to 74 per 10,000 persons; P = 0.035). For low-dose trials, the risk difference was -16 per 10,000 persons (CI, -41 to 10 per 10,000 persons; P > 0.2). - The dose response analysis showed a statistically significant difference between vitamin E dosage and all-cause mortality especially if doses exceeded 150 IU/day. |