Chronic Pain Studies

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The Placebo Controversy

Chronic pain, especially of the back, is one of the most common indications for which people seek acupuncture therapy.  Researchers have sought to prove or disprove its benefit, however, have been unsuccessful in reaching any conclusions.  To scientifically prove or validate a treatment or therapy, one must produce reproducible data from randomized, double-blinded studies of a statistically-significant patient population. 

Although numerous studies have set out to scientifically explain and prove the effects of acupuncture in chronic pain, most research is flawed, non-reproducible or not significant.  One of the major barriers to accurate assessment of the effects of acupuncture is the controversial choice of placebo.  For a discussion of the placebo controversy, click here.  Other barriers include the number of patients, multiple etiologies of pain, difficult to blind, variations in acupuncture and benefit assessment.

Below are brief synopses of some published studies and meta-analyses of the efficacy of acupuncture.

Studies or analyses supporting the use of acupuncture

  • A study reported by Lee and Andersen in 1975 demonstrated patients undergoing acupuncture for chronic pain had relief, although relief was independent of the use of acupuncture points.  The data came from 971 treatments in 261 patients.  No placebo was used.  Their data also support increasing relief with subsequent treatments.  Although their work suggests benefit from the use of acupuncture, their study was neither randomized nor controlled, and only the patients were blinded. 
  • A meta-analysis of randomized controlled trials was presented by Ernst and White in 1998 which indicated acupuncture to be superior to control methods, but not placebo.  Twelve studies were included, but only nine had suitable data.  Usable data came from studies employing traditional acupoints and different controls.  They found that the results of 4 sham controlled, evaluator-blinded studies did not show acupuncture to be better than placebo. 
  • A study reported by Ming-Ting Wu, et al in 1999 compared heart rate and brain activity using Functional MRI while patients received acupuncture at true Li and ST points and at random points. All patients received both true and false needling with a 20 minute interval between them. One group just tested Li points and the other only tested ST points. Results demonstrated a decrease in heart rate with all true points and an increase in activation of the hypothalamus and nucleus accumbens, with a deactivation of the rostral anterior cigulate cortex, amygdala, and hippocampal complex. There was no change in physiology with the false points. This may help to explain the analgesic effects of acupuncture.
  • A review by Kaptchuck in 2002 demonstrated acupuncture to be beneficial for nausea associated with pregnancy and post surgery or chemotherapy. There is also some evidence of benefit with dental pain. There continues to be inconclusive evidence supporting acupuncture for chronic back pain. Several Randomized control trials, meta analysis, and systematic reviews have been completed and many more are in the process to find a answer to the effectiveness of acupuncture. 

Studies or analyses not supporting the use of acupuncture

  • A double-blinded placebo-controlled trial was presented by Mendelson and Selwood in 1983.  77 patients were enrolled and monitored by questionnaire for improvement.  Placebo was in the form of superficial placement of the needles into a non-tender, non-acupuncture sites pretreated with lidocaine and no stimulation.  Their work showed no difference in efficacy between acupuncture and placebo:  a reduction in the pain score for acupuncture at 26 percent and 22 percent for placebo, p value greater than 0.6.  In fact, they concluded that the placebo component was more important clinically than the physiological. 
  • A systematic review of the Cochrane Collaboration Back Review Group revealed no clear conclusion could be made as to the effectiveness of acupuncture in the management of back pain.  Eleven randomized controlled studies were reviewed.  Results indicated acupuncture to be:
    • not more effective than trigger-point injections and transcutaneous electrical nerve stimulation, and
    • not more effective than placebo or sham acupuncture

    No evidence indicated acupuncture to be better than no treatment. 

  • A Systematic review by Ezzo, Berman, et al, in 2000 also did not show acupuncture to be less effective than placebo but there was limited evidence to prove that it is better than placebo.