What is Chelation Therapy

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What is Chelation Therapy?

    The term chelate is derived from the Greek word "chele"  which means to grasp with a pincer and was first applied to chemicals in 1920 by the analytical chemist G.T. Morgan.  Chelating agents are large anionic molecules that reversibly bind with high affinity to di- and tri- valent metal cations to form a metal complex.  Some common chelators are ethylenediamminetetraacetate (EDTA), dimercaprol (BAL), D-penicillamine, dimercaptosuccinic acid (DMSA), deferoxamine and natural chelators including hemoglobin and chlorophyll.  Both natural and synthetic chelating agents have many important uses in the areas of medicine, physiology and inorganic and organic chemistry.

    The proposed goal of chelation therapy is to remove harmful substances from the body by having a chelating agent form a complex with the toxic substance and allowing the body to remove that complex using its natural mechanisms of waste product removal.  Proponents of chelation therapy claim that it may be used to treat coronary artery disease, peripheral vascular disease, arthritis, multiple sclerosis, Parkinson's disease, psoriasis, Alzheimer's disease and many others.  Chelation therapy is routinely used and has been shown to be safe and effective for the treatment of heavy metal poisoning with lead, mercury, iron and for arsenic poisoning.  The most popular alternative use for chelation therapy is in the treatment of atherosclerotic diseases (CAD and peripheral vascular disease).

    Current descriptions by chelation proponents of chelation therapy treatments for cardiovascular disease include the intravenous administration of EDTA and the addition of several other components including B-complex vitamins, vitiamin C, minerals, heparin and magnesium sulfate.  More information on ingredients used in chelation therapy protocols can be found here: chelation protocols.  Patients are usually treated three times per week for an average of 40 total treatments at a cost of $100-$125 per treatment.

    Oral chelation is a second proposed mechanism of using chelating agents to treat a wide variety of disease.  Proponents of this form of chelation therapy make the same therapeutic claims as those who support IV chelation in addition to claiming a general cleansing effect with oral chelation.  Oral chelation may involve the use of oral preparations of EDTA or combinations of "natural" vitamins, minerals and other supplements that have inherent chelating properties.  The proponents of each type of chelation therapy seem, for the most part, to discount the therapeutic efficacy of the alternate therapy by claiming that the route of administration is integral to the therapeutic effect.