Contraindications

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Women who are pregnant or breastfeeding should avoid melatonin supplements as should people with autoimmune diseases, allergies, cardiovascular disease, depression, epilepsy or other seizure disorder, liver disease, immunosuppression, and drug or alcohol abuse.

High doses of melatonin have been associated with altered ovarian function and anovulation. Therefore, women trying to conceive should avoid it.

While taking melatonin, driving and operating other machinery should be avoided.

Other drugs that may interact with melatonin include: amphetamines, blood pressure medications such as nifedipine, other dietary supplements, hormonal medications, psychiatric medications, seizure medications, sedatives, and tamoxifen.

Melatonin is a dietary supplement, and all of the contraindications and possible drug interactions are not known. Therefore, you should consult a physician before taking it.