History

Home • AltMed Home • Search

 

History
Pharmacology
Depression
Scientific Review
Drug Safety
References
Links

 

 


 

St. John's wort, or latin Hypericum perforatum, is a five-petalled, yellow-flowered perennial weed common to the western United States, Europe and Asia.  The plant belongs to the family Hypericaceae.  It was named after St. John the Baptist since the herb produced yellow flowers particularly abundant on June 24, the day traditionally celebrated as his birthday.  Other Christian authors claimed that the red spots, symbolic of the blood of St. John, appeared on the leaves on August 29, the anniversary of his beheading.

From the time of the ancient Greeks down through the Middle ages, the plant was considered to be imbued with magical powers to ward off evil spirits and protect against various diseases.  St. John's wort, applied topically or systematically, has been used to treat bronchitis, burns, cancer, enuresis, gastritis, hemorrhoids, hypothyroidism, insect bites, insomnia, kidney disease, scabies, and wound healing.  In the late nineteenth century, it fell into disrepute like many plant drugs. 

In the 1940s, St. John's wort proved to be exceedingly troublesome to farmers in northern California and southern Oregon because of it's photosensitizing properties that can be toxic to cows and sheep and was given the name "Klamath weed".  It was estimated that over two million acres in northern California were overrun by the "Klamath weed".  After the use of herbicides failed, leaf beetles from Australia, Chrysolina quadrigemina Rossi were introduced for their voracious appetite for Hypericum.  The beetles were so effective that the number of St. John's wort was reduced to 1% of their original number.

Although the therapeutic use of St. John's wort is approved in Germany for psychoautonomic disturbances, depressive mood disorders, and anxiety, its popularity in the U.S. didn't arrive until 1997.  In June of that year, millions of Americans diagnosed themselves as mildly to moderately depressed after a feature on the plant by ABC's television news program 20/20. Product sales rose dramatically following the national media attention.  In 1998, St. John's wort was the second best selling herbal medicinal product, selling over $140 million.

Photo courtesy of B.C. Ministry of Agriculture, Food and Fisheries